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Goal-dependent dissociation of visual and prefrontal cortices during working memory.

ABSTRACT: To determine the specific contribution of brain regions to working memory, human participants performed two distinct tasks on the same visually presented objects. During the maintenance of visual properties, object identity could be decoded from extrastriate, but not prefrontal, cortex, whereas the opposite held for nonvisual properties. Thus, the ability to maintain information during working memory is a general and flexible cortical property, with the role of individual regions being goal-dependent.

SUBMITTER: Lee SH

PROVIDER: S-EPMC3781947 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Goal-dependent dissociation of visual and prefrontal cortices during working memory.

Lee Sue-Hyun SH Kravitz Dwight J DJ Baker Chris I CI

Nature neuroscience 20130630 8

To determine the specific contribution of brain regions to working memory, human participants performed two distinct tasks on the same visually presented objects. During the maintenance of visual properties, object identity could be decoded from extrastriate, but not prefrontal, cortex, whereas the opposite held for nonvisual properties. Thus, the ability to maintain information during working memory is a general and flexible cortical property, with the role of individual regions being goal-depe ...[more]

PMID: 23817547

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