Ontology highlight
ABSTRACT:
SUBMITTER: Niederreiter L
PROVIDER: S-EPMC3782039 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Niederreiter Lukas L Fritz Teresa M J TM Adolph Timon E TE Krismer Anna-Maria AM Offner Felix A FA Tschurtschenthaler Markus M Flak Magdalena B MB Hosomi Shuhei S Tomczak Michal F MF Kaneider Nicole C NC Sarcevic Edina E Kempster Sarah L SL Raine Tim T Esser Daniela D Rosenstiel Philip P Kohno Kenji K Iwawaki Takao T Tilg Herbert H Blumberg Richard S RS Kaser Arthur A
The Journal of experimental medicine 20130916 10
Unresolved endoplasmic reticulum (ER) stress in the epithelium can provoke intestinal inflammation. Hypomorphic variants of ER stress response mediators, such as X-box-binding protein 1 (XBP1), confer genetic risk for inflammatory bowel disease. We report here that hypomorphic Xbp1 function instructs a multilayered regenerative response in the intestinal epithelium. This is characterized by intestinal stem cell (ISC) expansion as shown by an inositol-requiring enzyme 1α (Ire1α)-mediated increase ...[more]