Structural disorder in expanding the functionome of aminoacyl-tRNA synthetases.
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ABSTRACT:
SUBMITTER: Yang XL
PROVIDER: S-EPMC3782743 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Structural disorder in expanding the functionome of aminoacyl-tRNA synthetases.
Chemistry & biology 20130901 9
Over the past decade, aminoacyl-tRNA synthetases (AARSs) have emerged as a new class of regulatory proteins with widespread functions beyond their classic role in protein synthesis. The functional expansion concurs with the incorporation of new domains and motifs to AARSs and coincides with the emergence of the multi-synthetase complex (MSC) during the course of eukaryotic evolution. Notably, the new domains in AARSs are often found to be structurally disordered or to be linked to the enzyme cor ...[more]
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