Unknown

Dataset Information

0

Influence of HLA-C expression level on HIV control.


ABSTRACT: A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of individual HLA allelic effects in both African and European Americans, regardless of their distinct HLA-C frequencies and linkage relationships with HLA-B and HLA-A. Higher HLA-C expression was correlated with increased likelihood of cytotoxic T lymphocyte responses and frequency of viral escape mutation. In contrast, high HLA-C expression had a deleterious effect in Crohn's disease, suggesting a broader influence of HLA expression levels in human disease.

SUBMITTER: Apps R 

PROVIDER: S-EPMC3784322 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Influence of HLA-C expression level on HIV control.

Apps Richard R   Qi Ying Y   Carlson Jonathan M JM   Chen Haoyan H   Gao Xiaojiang X   Thomas Rasmi R   Yuki Yuko Y   Del Prete Greg Q GQ   Goulder Philip P   Brumme Zabrina L ZL   Brumme Chanson J CJ   John Mina M   Mallal Simon S   Nelson George G   Bosch Ronald R   Heckerman David D   Stein Judy L JL   Soderberg Kelly A KA   Moody M Anthony MA   Denny Thomas N TN   Zeng Xue X   Fang Jingyuan J   Moffett Ashley A   Lifson Jeffrey D JD   Goedert James J JJ   Buchbinder Susan S   Kirk Gregory D GD   Fellay Jacques J   McLaren Paul P   Deeks Steven G SG   Pereyra Florencia F   Walker Bruce B   Michael Nelson L NL   Weintrob Amy A   Wolinsky Steven S   Liao Wilson W   Carrington Mary M  

Science (New York, N.Y.) 20130401 6128


A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of ind  ...[more]

Similar Datasets

| S-EPMC3084326 | biostudies-literature
| S-EPMC2887091 | biostudies-literature
| S-EPMC5933048 | biostudies-literature
| S-EPMC3166850 | biostudies-literature
| S-EPMC7668082 | biostudies-literature
| S-EPMC3365058 | biostudies-other
| S-EPMC3255844 | biostudies-other
| S-EPMC1654130 | biostudies-literature
| S-EPMC11291675 | biostudies-literature
| S-EPMC5177477 | biostudies-other