Ontology highlight
ABSTRACT:
SUBMITTER: Apps R
PROVIDER: S-EPMC3784322 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Apps Richard R Qi Ying Y Carlson Jonathan M JM Chen Haoyan H Gao Xiaojiang X Thomas Rasmi R Yuki Yuko Y Del Prete Greg Q GQ Goulder Philip P Brumme Zabrina L ZL Brumme Chanson J CJ John Mina M Mallal Simon S Nelson George G Bosch Ronald R Heckerman David D Stein Judy L JL Soderberg Kelly A KA Moody M Anthony MA Denny Thomas N TN Zeng Xue X Fang Jingyuan J Moffett Ashley A Lifson Jeffrey D JD Goedert James J JJ Buchbinder Susan S Kirk Gregory D GD Fellay Jacques J McLaren Paul P Deeks Steven G SG Pereyra Florencia F Walker Bruce B Michael Nelson L NL Weintrob Amy A Wolinsky Steven S Liao Wilson W Carrington Mary M
Science (New York, N.Y.) 20130401 6128
A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized the differential cell surface expression levels of all common HLA-C allotypes and tested directly for effects of HLA-C expression on outcomes of HIV infection in 5243 individuals. Increasing HLA-C expression was associated with protection against multiple outcomes independently of ind ...[more]