Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC3166850 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Zhang YongHong Y Peng YanChun Y Yan HuiPing H Xu Keyi K Saito Masumichi M Wu Hao H Chen XinYue X Ranasinghe Srinika S Kuse Nozomi N Powell Tim T Zhao Yan Y Li WeiHua W Zhang Xin X Feng Xia X Li Ning N Leligdowicz Aleksandra A Xu XiaoNing X John Mina M Takiguchi Masafumi M McMichael Andrew A Rowland-Jones Sarah S Dong Tao T
Journal of immunology (Baltimore, Md. : 1950) 20110613 2
Polymorphism in the HLA region of a chromosome is the major source of host genetic variability in HIV-1 outcome, but there is limited understanding of the mechanisms underlying the beneficial effect of protective class I alleles such as HLA-B57, -B27, and -B51. Taking advantage of a unique cohort infected with clade B' HIV-1 through contaminated blood, in which many variables such as the length of infection, the infecting viral strain, and host genetic background are controlled, we performed a c ...[more]