Ontology highlight
ABSTRACT:
SUBMITTER: Grundberg E
PROVIDER: S-EPMC3784328 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Nature genetics 20120902 10
Sequence-based variation in gene expression is a key driver of disease risk. Common variants regulating expression in cis have been mapped in many expression quantitative trait locus (eQTL) studies, typically in single tissues from unrelated individuals. Here, we present a comprehensive analysis of gene expression across multiple tissues conducted in a large set of mono- and dizygotic twins that allows systematic dissection of genetic (cis and trans) and non-genetic effects on gene expression. U ...[more]