Ontology highlight
ABSTRACT:
SUBMITTER: Edwards M
PROVIDER: S-EPMC3784379 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Edwards Marc M Liang Yun Y Kim Taekyung T Cooper John A JA
Molecular biology of the cell 20130731 19
The regulation of free barbed ends is central to the control of dynamic actin assembly and actin-based motility in cells. Capping protein (CP) is known to regulate barbed ends and control actin assembly in cells. The CARMIL family of proteins can bind and inhibit CP in vitro, but the physiological significance of the interaction of CARMIL with CP in cells is poorly understood. Mammalian cells lacking CARMIL1 have defects in lamellipodia, macropinocytosis, cell migration, and Rac1 activation. Her ...[more]