Ontology highlight
ABSTRACT:
SUBMITTER: Edwards M
PROVIDER: S-EPMC4598739 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Edwards Marc M McConnell Patrick P Schafer Dorothy A DA Cooper John A JA
Nature communications 20150928
Capping protein (CP) has critical roles in actin assembly in vivo and in vitro. CP binds with high affinity to the barbed end of actin filaments, blocking the addition and loss of actin subunits. Heretofore, models for actin assembly in cells generally assumed that CP is constitutively active, diffusing freely to find and cap barbed ends. However, CP can be regulated by binding of the 'capping protein interaction' (CPI) motif, found in a diverse and otherwise unrelated set of proteins that decre ...[more]