Ontology highlight
ABSTRACT:
SUBMITTER: Martin H
PROVIDER: S-EPMC3784531 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Martin Holly H Mali Raghuveer Singh RS Ma Peilin P Chatterjee Anindya A Ramdas Baskar B Sims Emily E Munugalavadla Veerendra V Ghosh Joydeep J Mattingly Ray R RR Visconte Valeria V Tiu Ramon V RV Vlaar Cornelis P CP Dharmawardhane Suranganie S Kapur Reuben R
The Journal of clinical investigation 20130916 10
An acquired somatic mutation at codon 816 in the KIT receptor tyrosine kinase is associated with poor prognosis in patients with systemic mastocytosis and acute myeloid leukemia (AML). Treatment of leukemic cells bearing this mutation with an allosteric inhibitor of p21-activated kinase (Pak) or its genetic inactivation results in growth repression due to enhanced apoptosis. Inhibition of the upstream effector Rac abrogates the oncogene-induced growth and activity of Pak. Although both Rac1 and ...[more]