Ontology highlight
ABSTRACT:
SUBMITTER: Lister R
PROVIDER: S-EPMC3785061 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Lister Ryan R Mukamel Eran A EA Nery Joseph R JR Urich Mark M Puddifoot Clare A CA Johnson Nicholas D ND Lucero Jacinta J Huang Yun Y Dwork Andrew J AJ Schultz Matthew D MD Yu Miao M Tonti-Filippini Julian J Heyn Holger H Hu Shijun S Wu Joseph C JC Rao Anjana A Esteller Manel M He Chuan C Haghighi Fatemeh G FG Sejnowski Terrence J TJ Behrens M Margarita MM Ecker Joseph R JR
Science (New York, N.Y.) 20130704 6146
DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, b ...[more]