Unknown

Dataset Information

0

Global epigenomic reconfiguration during mammalian brain development.


ABSTRACT: DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, but not glia, to become the dominant form of methylation in the human neuronal genome. Moreover, we found an mCH signature that identifies genes escaping X-chromosome inactivation. Last, whole-genome single-base resolution 5-hydroxymethylcytosine (hmC) maps revealed that hmC marks fetal brain cell genomes at putative regulatory regions that are CG-demethylated and activated in the adult brain and that CG demethylation at these hmC-poised loci depends on Tet2 activity.

SUBMITTER: Lister R 

PROVIDER: S-EPMC3785061 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications


DNA methylation is implicated in mammalian brain development and plasticity underlying learning and memory. We report the genome-wide composition, patterning, cell specificity, and dynamics of DNA methylation at single-base resolution in human and mouse frontal cortex throughout their lifespan. Widespread methylome reconfiguration occurs during fetal to young adult development, coincident with synaptogenesis. During this period, highly conserved non-CG methylation (mCH) accumulates in neurons, b  ...[more]

Similar Datasets

2013-07-03 | GSE47966 | GEO
| PRJNA208503 | ENA
| S-EPMC4499463 | biostudies-literature
| S-EPMC3088578 | biostudies-literature
| S-EPMC8591371 | biostudies-literature
| S-EPMC7857341 | biostudies-literature
| S-EPMC5599895 | biostudies-literature
| S-EPMC7229188 | biostudies-literature
| S-EPMC7125157 | biostudies-literature
| S-EPMC8616463 | biostudies-literature