Epigenomic programming in early fetal brain development.
Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC7857341 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Epigenomic programming in early fetal brain development.
Li Luolan L Maire Cecile L CL Bilenky Misha M Carles Annaïck A Heravi-Moussavi Alireza A Hong Chibo C Tam Angela A Kamoh Baljit B Cho Stephanie S Cheung Dorothy D Li Irene I Wong Tina T Nagarajan Raman P RP Mungall Andrew J AJ Moore Richard R Wang Ting T Kleinman Claudia L CL Jabado Nada N Jones Steven Jm SJ Marra Marco A MA Ligon Keith L KL Costello Joseph F JF Hirst Martin M
Epigenomics 20200601 12
<b>Aim:</b> To provide a comprehensive understanding of gene regulatory networks in the developing human brain and a foundation for interpreting pathogenic deregulation. <b>Materials & methods:</b> We generated reference epigenomes and transcriptomes of dissected brain regions and primary neural progenitor cells (NPCs) derived from cortical and ganglionic eminence tissues of four normal human fetuses. <b>Results:</b> Integration of these data across developmental stages revealed a directional in ...[more]
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