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Enantioselective ?-alkenylation of aldehydes with boronic acids via the synergistic combination of copper(II) and amine catalysis.


ABSTRACT: The enantioselective ?-alkenylation of aldehydes has been accomplished using boronic acids via the synergistic combination of copper and chiral amine catalysis. The merger of two highly utilized and robust catalytic systems has allowed for the development of a mild and operationally trivial protocol for the direct formation of ?-formyl olefins employing common building blocks for organic synthesis.

SUBMITTER: Stevens JM 

PROVIDER: S-EPMC3785792 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Enantioselective α-alkenylation of aldehydes with boronic acids via the synergistic combination of copper(II) and amine catalysis.

Stevens Jason M JM   MacMillan David W C DW  

Journal of the American Chemical Society 20130805 32


The enantioselective α-alkenylation of aldehydes has been accomplished using boronic acids via the synergistic combination of copper and chiral amine catalysis. The merger of two highly utilized and robust catalytic systems has allowed for the development of a mild and operationally trivial protocol for the direct formation of α-formyl olefins employing common building blocks for organic synthesis. ...[more]

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