Ontology highlight
ABSTRACT:
SUBMITTER: Ramamoorthy M
PROVIDER: S-EPMC3786377 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Ramamoorthy Mahesh M May Alfred A Tadokoro Takashi T Popuri Venkateswarlu V Seidman Michael M MM Croteau Deborah L DL Bohr Vilhelm A VA
Carcinogenesis 20130528 10
Interstrand cross-links (ICLs) are very severe lesions as they are absolute blocks of replication and transcription. This property of interstrand cross-linking agents has been exploited clinically for the treatment of cancers and other diseases. ICLs are repaired in human cells by specialized DNA repair pathways including components of the nucleotide excision repair pathway, double-strand break repair pathway and the Fanconi anemia pathway. In this report, we identify the role of RECQL5, a membe ...[more]