Ontology highlight
ABSTRACT:
SUBMITTER: Long DT
PROVIDER: S-EPMC4068331 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Long David T DT Räschle Markus M Joukov Vladimir V Walter Johannes C JC
Science (New York, N.Y.) 20110701 6038
DNA interstrand cross-links (ICLs) are toxic DNA lesions whose repair in S phase of eukaryotic cells is incompletely understood. In Xenopus egg extracts, ICL repair is initiated when two replication forks converge on the lesion. Dual incisions then create a DNA double-strand break (DSB) in one sister chromatid, whereas lesion bypass restores the other sister. We report that the broken sister chromatid is repaired via RAD51-dependent strand invasion into the regenerated sister. Recombination acts ...[more]