Ontology highlight
ABSTRACT:
SUBMITTER: Botzolakis EJ
PROVIDER: S-EPMC3786708 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Botzolakis E J EJ Maheshwari A A Feng H J HJ Lagrange A H AH Shaver J H JH Kassebaum N J NJ Venkataraman R R Baudenbacher F F Macdonald R L RL
Journal of neuroscience methods 20081021 2
Fast synaptic transmission is mediated by post-synaptic ligand-gated ion channels (LGICs) transiently activated by neurotransmitter released from pre-synaptic vesicles. Although disruption of synaptic transmission has been implicated in numerous neurological and psychiatric disorders, effective and practical methods for studying LGICs in vitro under synaptically relevant conditions are unavailable. Here, we describe a novel microfluidic approach to solution switching that allows for precise temp ...[more]