Ontology highlight
ABSTRACT:
SUBMITTER: Poulton JS
PROVIDER: S-EPMC3787761 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Poulton John S JS Mu Frank W FW Roberts David M DM Peifer Mark M
Development (Cambridge, England) 20130911 20
To ensure the accurate transmission of genetic material, chromosome segregation must occur with extremely high fidelity. Segregation errors lead to chromosomal instability (CIN), with deleterious consequences. Mutations in the tumor suppressor adenomatous polyposis coli (APC) initiate most colon cancers and have also been suggested to promote disease progression through increased CIN, but the mechanistic role of APC in preventing CIN remains controversial. Using fly embryos as a model, we invest ...[more]