Ontology highlight
ABSTRACT:
SUBMITTER: Mardin BR
PROVIDER: S-EPMC3939353 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Mardin Balca R BR Isokane Mayumi M Cosenza Marco R MR Krämer Alwin A Ellenberg Jan J Fry Andrew M AM Schiebel Elmar E
Developmental cell 20130502 3
Timely and accurate assembly of the mitotic spindle is critical for the faithful segregation of chromosomes, and centrosome separation is a key step in this process. The timing of centrosome separation varies dramatically between cell types; however, the mechanisms responsible for these differences and its significance are unclear. Here, we show that activation of epidermal growth factor receptor (EGFR) signaling determines the timing of centrosome separation. Premature separation of centrosomes ...[more]