Unknown

Dataset Information

0

Unbalanced estrogen metabolism in thyroid cancer.


ABSTRACT: Well-differentiated thyroid cancer most frequently occurs in premenopausal women. Greater exposure to estrogens may be a risk factor for thyroid cancer. To investigate the role of estrogens in thyroid cancer, a spot urine sample was obtained from 40 women with thyroid cancer and 40 age-matched controls. Thirty-eight estrogen metabolites, conjugates and DNA adducts were analyzed by using ultraperformance liquid chromatography/tandem mass spectrometry and the ratio of adducts to metabolites and conjugates was calculated for each sample. The ratio of depurinating estrogen-DNA adducts to estrogen metabolites and conjugates significantly differed between cases and controls (p < 0.0001), demonstrating high specificity and sensitivity. These findings indicate that estrogen metabolism is unbalanced in thyroid cancer and suggest that formation of estrogen-DNA adducts might play a role in the initiation of thyroid cancer.

SUBMITTER: Zahid M 

PROVIDER: S-EPMC3788045 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Unbalanced estrogen metabolism in thyroid cancer.

Zahid Muhammad M   Goldner Whitney W   Beseler Cheryl L CL   Rogan Eleanor G EG   Cavalieri Ercole L EL  

International journal of cancer 20130614 11


Well-differentiated thyroid cancer most frequently occurs in premenopausal women. Greater exposure to estrogens may be a risk factor for thyroid cancer. To investigate the role of estrogens in thyroid cancer, a spot urine sample was obtained from 40 women with thyroid cancer and 40 age-matched controls. Thirty-eight estrogen metabolites, conjugates and DNA adducts were analyzed by using ultraperformance liquid chromatography/tandem mass spectrometry and the ratio of adducts to metabolites and co  ...[more]

Similar Datasets

| S-EPMC3949171 | biostudies-literature
| S-EPMC10712093 | biostudies-literature
| S-EPMC4505810 | biostudies-literature
| S-EPMC10177023 | biostudies-literature
| S-EPMC9263191 | biostudies-literature
| S-EPMC7179243 | biostudies-literature
| S-EPMC5288210 | biostudies-literature
| S-EPMC3283536 | biostudies-literature
| S-EPMC4429663 | biostudies-literature
| S-EPMC2764317 | biostudies-literature