Unknown

Dataset Information

0

Unbalanced estrogen metabolism in ovarian cancer.


ABSTRACT: Greater exposure to estrogens is a risk factor for ovarian cancer. To investigate the role of estrogens in ovarian cancer, a spot urine sample and a saliva sample were obtained from 33 women with ovarian cancer and 34 age-matched controls. Thirty-eight estrogen metabolites, conjugates and DNA adducts were analyzed in the urine samples using ultraperformance liquid chromatography/tandem mass spectrometry, and the ratio of adducts to metabolites and conjugates was calculated for each sample. The ratio of depurinating estrogen-DNA adducts to estrogen metabolites and conjugates was significantly higher in cases compared to controls (p?

SUBMITTER: Zahid M 

PROVIDER: S-EPMC3949171 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

Unbalanced estrogen metabolism in ovarian cancer.

Zahid Muhammad M   Beseler Cheryl L CL   Hall James B JB   LeVan Tricia T   Cavalieri Ercole L EL   Rogan Eleanor G EG  

International journal of cancer 20140125 10


Greater exposure to estrogens is a risk factor for ovarian cancer. To investigate the role of estrogens in ovarian cancer, a spot urine sample and a saliva sample were obtained from 33 women with ovarian cancer and 34 age-matched controls. Thirty-eight estrogen metabolites, conjugates and DNA adducts were analyzed in the urine samples using ultraperformance liquid chromatography/tandem mass spectrometry, and the ratio of adducts to metabolites and conjugates was calculated for each sample. The r  ...[more]

Similar Datasets

| S-EPMC3788045 | biostudies-literature
| S-EPMC4429663 | biostudies-literature
| S-EPMC4505810 | biostudies-literature
| S-EPMC5133706 | biostudies-other
| S-EPMC7641961 | biostudies-literature
| S-EPMC7179243 | biostudies-literature
| S-EPMC5564823 | biostudies-literature
| S-EPMC3283536 | biostudies-literature
| S-EPMC5173084 | biostudies-literature
| S-EPMC8452972 | biostudies-literature