Unbalanced estrogen metabolism in ovarian cancer.
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ABSTRACT:
SUBMITTER: Zahid M
PROVIDER: S-EPMC3949171 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Unbalanced estrogen metabolism in ovarian cancer.
Zahid Muhammad M Beseler Cheryl L CL Hall James B JB LeVan Tricia T Cavalieri Ercole L EL Rogan Eleanor G EG
International journal of cancer 20140125 10
Greater exposure to estrogens is a risk factor for ovarian cancer. To investigate the role of estrogens in ovarian cancer, a spot urine sample and a saliva sample were obtained from 33 women with ovarian cancer and 34 age-matched controls. Thirty-eight estrogen metabolites, conjugates and DNA adducts were analyzed in the urine samples using ultraperformance liquid chromatography/tandem mass spectrometry, and the ratio of adducts to metabolites and conjugates was calculated for each sample. The r ...[more]
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