Ontology highlight
ABSTRACT:
SUBMITTER: Pryde DC
PROVIDER: S-EPMC3788104 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Pryde David C DC Jones Lyn H LH Gervais David P DP Stead David R DR Blakemore David C DC Selby Matthew D MD Brown Alan D AD Coe Jotham W JW Badland Matthew M Beal David M DM Glen Rebecca R Wharton Yvonne Y Miller Gavin J GJ White Phil P Zhang Ningli N Benoit Michelle M Robertson Karen K Merson James R JR Davis Heather L HL McCluskie Michael J MJ
PloS one 20131001 10
Anti-nicotine vaccines may aid smoking cessation via the induction of anti-nicotine antibodies (Ab) which reduce nicotine entering the brain, and hence the associated reward. Ab function depends on both the quantity (titer) and the quality (affinity) of the Ab. Anti-nicotine vaccines tested previously in clinical studies had poor efficacy despite high Ab titer, and this may be due to inadequate function if Ab of low affinity were induced. In this study, we designed and synthesized a series of no ...[more]