Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.
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ABSTRACT:
SUBMITTER: Stratton MM
PROVIDER: S-EPMC3788167 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
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Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II.
Stratton Margaret M MM Chao Luke H LH Schulman Howard H Kuriyan John J
Current opinion in structural biology 20130427 2
Ca(2+)/calmodulin dependent protein kinase II (CaMKII) is a broadly distributed metazoan Ser/Thr protein kinase that is important in neuronal and cardiac signaling. CaMKII forms oligomeric assemblies, typically dodecameric, in which the calcium-responsive kinase domains are organized around a central hub. We review the results of crystallographic analyses of CaMKII, including the recently determined structure of a full-length and autoinhibited form of the holoenzyme. These structures, when combi ...[more]
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