Ontology highlight
ABSTRACT:
SUBMITTER: Huang L
PROVIDER: S-EPMC3788571 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Huang Lei L Li Lingqian L Lemos Henrique H Chandler Phillip R PR Pacholczyk Gabriela G Baban Babak B Barber Glen N GN Hayakawa Yoshihiro Y McGaha Tracy L TL Ravishankar Buvana B Munn David H DH Mellor Andrew L AL
Journal of immunology (Baltimore, Md. : 1950) 20130828 7
Cytosolic DNA sensing via the stimulator of IFN genes (STING) adaptor incites autoimmunity by inducing type I IFN (IFN-αβ). In this study, we show that DNA is also sensed via STING to suppress immunity by inducing IDO. STING gene ablation abolished IFN-αβ and IDO induction by dendritic cells (DCs) after DNA nanoparticle (DNP) treatment. Marginal zone macrophages, some DCs, and myeloid cells ingested DNPs, but CD11b(+) DCs were the only cells to express IFN-β, whereas CD11b(+) non-DCs were major ...[more]