Ontology highlight
ABSTRACT:
SUBMITTER: Benedek G
PROVIDER: S-EPMC3788583 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Benedek Gil G Meza-Romero Roberto R Andrew Shayne S Leng Lin L Burrows Gregory G GG Bourdette Dennis D Offner Halina H Bucala Richard R Vandenbark Arthur A AA
European journal of immunology 20130410 5
MIF and its receptor, CD74, are pivotal regulators of the immune system. Here, we demonstrate for the first time that partial MHC class II constructs comprised of linked β1α1 domains with covalently attached antigenic peptides (also referred to as recombinant T-cell receptor ligands - RTLs) can inhibit MIF activity by not only blocking the binding of rhMIF to immunopurified CD74, but also downregulating CD74 cell-surface expression. This bifunctional inhibition of MIF/CD74 interactions blocked d ...[more]