Ontology highlight
ABSTRACT:
SUBMITTER: Meza-Romero R
PROVIDER: S-EPMC4028955 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Meza-Romero Roberto R Benedek Gil G Yu Xiaolin X Mooney Jeffery L JL Dahan Rony R Duvshani Nerri N Bucala Richard R Offner Halina H Reiter Yoram Y Burrows Gregory G GG Vandenbark Arthur A AA
Journal of immunology (Baltimore, Md. : 1950) 20140328 9
CD74, the cell-surface form of the MHC class II invariant chain, is a key inflammatory factor that is involved in various immune-mediated diseases as part of the macrophage migration inhibitory factor (MIF) binding complex. However, little is known about the natural regulators of CD74 in this context. In order to study the role of the HLA-DR molecule in regulating CD74, we used the HLA-DRα1 domain, which was shown to bind to and downregulate CD74 on CD11b(+) monocytes. We found that DRα1 directl ...[more]