Ontology highlight
ABSTRACT:
SUBMITTER: Shoji-Kawata S
PROVIDER: S-EPMC3788641 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Shoji-Kawata Sanae S Sumpter Rhea R Leveno Matthew M Campbell Grant R GR Zou Zhongju Z Kinch Lisa L Wilkins Angela D AD Sun Qihua Q Pallauf Kathrin K MacDuff Donna D Huerta Carlos C Virgin Herbert W HW Helms J Bernd JB Eerland Ruud R Tooze Sharon A SA Xavier Ramnik R Lenschow Deborah J DJ Yamamoto Ai A King David D Lichtarge Olivier O Grishin Nick V NV Spector Stephen A SA Kaloyanova Dora V DV Levine Beth B
Nature 20130130 7436
The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly, agents that induce autophagy may have broad therapeutic applications. One approach to developing such agents is to exploit autophagy manipulation strategies used by microbial virulence factors. Here we show that a peptide, Tat-beclin 1-derived from a region of the autophagy protein, beclin 1, which binds human immunodeficiency virus (HIV)-1 ...[more]