Ontology highlight
ABSTRACT:
SUBMITTER: Kim SE
PROVIDER: S-EPMC3788643 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130411 6134
Wnt signaling stabilizes β-catenin through the LRP6 receptor signaling complex, which antagonizes the β-catenin destruction complex. The Axin scaffold and associated glycogen synthase kinase-3 (GSK3) have central roles in both assemblies, but the transduction mechanism from the receptor to the destruction complex is contentious. We report that Wnt signaling is governed by phosphorylation regulation of the Axin scaffolding function. Phosphorylation by GSK3 kept Axin activated ("open") for β-caten ...[more]