Ontology highlight
ABSTRACT:
SUBMITTER: Wagner CS
PROVIDER: S-EPMC3789698 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Wagner Claudia S CS Grotzke Jeff J Cresswell Peter P
PloS one 20131003 10
We have investigated the effect of different maturation stimuli on the ability of mature dendritic cells (DCs) to cross-present newly acquired particulate antigens. Cross-presentation was impaired in DCs matured by treatment with TNF-α, CpG and LPS, but was less affected upon CD40L-induced maturation. The difference could not be explained by decreased antigen uptake or translocation into the cytosol, but decreased cross-presentation ability did correlate with increased phagosomal/lysosomal acidi ...[more]