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Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton.


ABSTRACT: Digging up skeletons: We report the identification and the functional characterization of two terpene cyclases (DtcycA and DtcycB) that were mined from the genome of Streptomyces sp. SANK 60404. DtcycA and DtcycB are novel bacterial diterpene cyclases for the synthesis of the cembrane skeleton.

SUBMITTER: Meguro A 

PROVIDER: S-EPMC3790952 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature

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Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton.

Meguro Ayuko A   Tomita Takeo T   Nishiyama Makoto M   Kuzuyama Tomohisa T  

Chembiochem : a European journal of chemical biology 20130201 3


Digging up skeletons: We report the identification and the functional characterization of two terpene cyclases (DtcycA and DtcycB) that were mined from the genome of Streptomyces sp. SANK 60404. DtcycA and DtcycB are novel bacterial diterpene cyclases for the synthesis of the cembrane skeleton. ...[more]

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