Ontology highlight
ABSTRACT:
SUBMITTER: Misch EA
PROVIDER: S-EPMC3791179 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Misch E A EA Verbon A A Prins J M JM Skerrett S J SJ Hawn T R TR
Genes and immunity 20130704 7
Legionella pneumophila (Lp), the etiologic agent of Legionnaires' disease (LD), is an important cause of community-acquired and nosocomial pneumonia. However, the host immune and genetic determinants of human susceptibility to Lp are poorly understood. Here we show that both TLR6 and TLR1 cooperate with TLR2 to recognize Lp in transfected HEK293 cells. We also perform a human genetic association study of 14 candidate single-nucleotide polymorphisms in Toll-like receptors (TLRs) 1, 2 and 6 in 98 ...[more]