Ontology highlight
ABSTRACT:
SUBMITTER: Ito K
PROVIDER: S-EPMC3791473 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Ito Keisuke K Hikida Aya A Kawai Shun S Lan Vu Thi Tuyet VT Motoyama Takayasu T Kitagawa Sayuri S Yoshikawa Yuko Y Kato Ryuji R Kawarasaki Yasuaki Y
Nature communications 20130101
Peptide uptake systems that involve members of the proton-coupled oligopeptide transporter (POT) family are conserved across all organisms. POT proteins have characteristic substrate multispecificity, with which one transporter can recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. Here we characterize the substrate multispecificity of Ptr2p, a major peptide transporter of Saccharomyces cerevisiae, using a dipeptide library. The affinities (Ki) of di/tripeptides t ...[more]