Ontology highlight
ABSTRACT:
SUBMITTER: Fowler PW
PROVIDER: S-EPMC4321885 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Fowler Philip W PW Orwick-Rydmark Marcella M Radestock Sebastian S Solcan Nicolae N Dijkman Patricia M PM Lyons Joseph A JA Kwok Jane J Caffrey Martin M Watts Anthony A Forrest Lucy R LR Newstead Simon S
Structure (London, England : 1993) 20150201 2
Proton-coupled oligopeptide transporters belong to the major facilitator superfamily (MFS) of membrane transporters. Recent crystal structures suggest the MFS fold facilitates transport through rearrangement of their two six-helix bundles around a central ligand binding site; how this is achieved, however, is poorly understood. Using modeling, molecular dynamics, crystallography, functional assays, and site-directed spin labeling combined with double electron-electron resonance (DEER) spectrosco ...[more]