Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC3791784 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Wang Xuan X Jiang Lin L Wallerman Ola O Engström Ulla U Ameur Adam A Gupta Rajesh Kumar RK Qi Yu Y Andersson Leif L Welsh Nils N
Proceedings of the National Academy of Sciences of the United States of America 20130916 40
We have investigated whether the recently discovered transcription factor, zinc finger BED domain-containing protein 6 (ZBED6), is expressed in insulin-producing cells and, if so, to what extent it affects beta cell function. ZBED6 was translated from a ZC3H11A transcript in which the ZBED6-containing intron was retained. ZBED6 was present in mouse βTC-6 cells and human islets as a double nuclear band at 115/120 kDa and as a single cytoplasmic band at 95-100 kDa, which lacked N-terminal nuclear ...[more]