Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi H
PROVIDER: S-EPMC3791788 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Takeuchi Hiroko H Kato Hiroyuki H Kurahashi Takashi T
Proceedings of the National Academy of Sciences of the United States of America 20130916 40
We investigated the sensitivity of single olfactory receptor cells to 2,4,6-trichloroanisole (TCA), a compound known for causing cork taint in wines. Such off-flavors have been thought to originate from unpleasant odor qualities evoked by contaminants. However, we here show that TCA attenuates olfactory transduction by suppressing cyclic nucleotide-gated channels, without evoking odorant responses. Surprisingly, suppression was observed even at extremely low (i.e., attomolar) TCA concentrations. ...[more]