Ontology highlight
ABSTRACT:
SUBMITTER: Von Dannecker LE
PROVIDER: S-EPMC6724935 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Von Dannecker Luiz Eduardo C LE Mercadante Adriana F AF Malnic Bettina B
The Journal of neuroscience : the official journal of the Society for Neuroscience 20050401 15
The olfactory system is able to detect a large number of chemical structures with a remarkable sensitivity and specificity. Odorants are first detected by odorant receptors present in the cilia of olfactory neurons. The activated receptors couple to an olfactory-specific G-protein (Golf), which activates adenylyl cyclase III to produce cAMP. Increased cAMP levels activate cyclic nucleotide-gated channels, causing cell membrane depolarization. Here we used yeast two-hybrid to search for potential ...[more]