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Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature.

ABSTRACT: The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent through enthalpy-entropy compensation.

SUBMITTER: Wang S 

PROVIDER: S-EPMC3791883 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature

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Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature.

Wang Shuo S   Kumar Arvind A   Aston Karl K   Nguyen Binh B   Bashkin James K JK   Boykin David W DW   Wilson W David WD  

Chemical communications (Cambridge, England) 20131001 76

The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent through enthalpy-entropy compensation. ...[more]

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