Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12.
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ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC379200 | biostudies-literature | 2002 Sep
REPOSITORIES: biostudies-literature
Publications
Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12.
Xu Jianfeng J Bleecker Eugene R ER Jongepier Hajo H Howard Timothy D TD Koppelman Gerard H GH Postma Dirkje S DS Meyers Deborah A DA
American journal of human genetics 20020715 3
Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LO ...[more]
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