Ontology highlight
ABSTRACT:
SUBMITTER: Conti DV
PROVIDER: S-EPMC379228 | biostudies-literature | 2003 Feb
REPOSITORIES: biostudies-literature
American journal of human genetics 20030113 2
Linkage disequilibrium (LD) mapping offers much promise for the positional cloning of disease-causing genes. However, conventional estimates of LD may fluctuate substantially across contiguous genomic regions, because of population-specific phenomena such as mutation, genetic drift, population structure, and variations in allele frequencies. This fluctuation makes it difficult to interpret patterns of LD and distinguish where a causal gene is located. To address this issue, we propose hierarchic ...[more]