Ontology highlight
ABSTRACT:
SUBMITTER: Carr SB
PROVIDER: S-EPMC3792671 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Carr Stephen B SB Mecia Lauren B LB Phillips Simon E V SE Thomas Christopher D CD
Acta crystallographica. Section F, Structural biology and crystallization communications 20130928 Pt 10
Antibiotic resistance in bacterial pathogens poses an ever-increasing risk to human health. In antibiotic-resistant strains of Staphylococcus aureus this resistance often resides in extra-chromosomal plasmids, such as those of the pT181 family, which replicate via a rolling-circle mechanism mediated by a plasmid-encoded replication initiation protein. Currently, there is no structural information available for the pT181-family Rep proteins. Here, the crystallization of a catalytically active fra ...[more]