Dataset Information

Association between Mannose-binding lectin gene polymorphisms and hepatitis B virus infection: a meta-analysis.

ABSTRACT:

Objective

The results of studies on the relation between Mannose-binding lectin gene (mbl2) polymorphism and HBV infection were contradictory and inconclusive. In order to shed a light on these inconsistent findings and to clarify the role of mbl2 polymorphisms in susceptibility or progression of chronic hepatitis B (CHB), a meta-analysis was performed.

Methods

PubMed and Embase were searched for available articles. A meta-analysis was performed to examine the association between mbl2 polymorphisms and chronicity or progression of hepatitis B infection. Odds ratio (OR) and its 95% confidence interval (CI) served as indexes.

Results

A total of 17 eligible studies were involved, including 2151 healthy controls (HC), 1293 spontaneous recovered (SR) patients with acute infection, 2337 cases with chronic hepatitis B (CHB) and 554 cases with progressive hepatitis B. There was no evidence of significant association between mbl2 exon1 polymorphisms and CHB risk in any genetic model or pairwise comparisons when compared with HC group or SR group. In the stratified analysis of ethnic groups, also no obvious relation between mbl2 polymorphism and CHB risk was identified. There was still no significant association between the complete mbl2 genotypic profile (including both the exon1 and the promoter gene) polymorphisms and CHB risk, as compared with SR group. However, it was found that there was an association between the mbl2 AO/OO genotype and severe hepatitis B (SHB) or liver cirrhosis (LC) (LC vs. HC:OR=3.66, 95%CI, 2.38-5.63; SHB vs. HC, OR=3.88, 95%CI, 2.26-6.64), but there was no relationship between the mbl2 AO/OO genotype and hepatocellular carcinoma (HCC) (OR=1.26, 95%CI, 0.82-1.94).

Conclusion

The present meta-analysis indicated that mbl2 exon1 polymorphisms might not significantly associate with chronicity of HBV infection, but might be significantly related to the progressive HBV such as SHB and LC.

SUBMITTER: Xu HD

PROVIDER: S-EPMC3792921 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Association between Mannose-binding lectin gene polymorphisms and hepatitis B virus infection: a meta-analysis.

Xu Hang-di HD Zhao Ming-fei MF Wan Tian-hong TH Song Guang-zhong GZ He Ji-liang JL Chen Zhi Z

PloS one 20131008 10

<h4>Objective</h4>The results of studies on the relation between Mannose-binding lectin gene (mbl2) polymorphism and HBV infection were contradictory and inconclusive. In order to shed a light on these inconsistent findings and to clarify the role of mbl2 polymorphisms in susceptibility or progression of chronic hepatitis B (CHB), a meta-analysis was performed.<h4>Methods</h4>PubMed and Embase were searched for available articles. A meta-analysis was performed to examine the association between ...[more]

PMID: 24116040

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Project description:ObjectivesMannose-binding lectin (MBL) is an important component of innate immunity. Structural and promoter polymorphisms in the MBL2 gene that are responsible for low MBL levels are associated with susceptibility to infectious diseases. The objective of this study was to investigate the association of serum MBL levels and MBL2 polymorphisms with persistent Staphylococcus aureus bacteremia (SAB) in adult Korean patients.MethodsWe conducted a case-control study nested in a prospective cohort of patients with SAB. The study compared 41 patients with persistent bacteremia (?7 days) and 46 patients with resolving bacteremia (<3 days). In each subject, we genotyped six single-nucleotide polymorphisms in the promoter region (alleles H/L, X/Y, and P/Q) and exon 1 (alleles A/B, A/C, and A/D) of the MBL2 gene and measured serum MBL concentrations. We also compared MBL2 genotypes between SAB patients and healthy people.ResultsPatients with persistent bacteremia were significantly more likely to have low/deficient MBL-producing genotypes and resultant low serum MBL levels, than were patients with resolving bacteremia (P?=?0.019 and P?=?0.012, respectively). Independent risk factors for persistent bacteremia were metastatic infection (adjusted odds ratio [aOR], 34.7; 95% confidence interval [CI], 12.83-196.37; P?=?0.003), methicillin resistance (aOR, 4.10; 95% CI, 3.19-29.57; P?=?0.025), and low/deficient MBL-producing genotypes (aOR, 7.64; 95% CI, 4.12-63.39; P?=?0.003). Such genotypes were significantly more common in patients with persistent bacteremia than in healthy people (OR, 2.09; 95% CI, 1.03-4.26; P?=?0.040).ConclusionsThis is the first demonstration of an association of low MBL levels and MBL2 polymorphisms responsible for low or deficient MBL levels with persistent SAB. A combination of factors, including clinical and microbiological characteristics and host defense factors such as MBL levels, may together contribute to the development of persistent SAB.

Project description:BACKGROUND:Immune- and inflammation-related genes (IIRGs) play an important role in the pathogenesis of tuberculosis (TB). However, the relationship between IIRG polymorphisms and TB risk remains unknown. In this study, the gene polymorphisms and their association with tuberculosis were determined in a Chinese population. METHODS:We performed a case-control study involving 1016 patients with TB and 507 healthy controls of Han Chinese origin. Sixty-four single-nucleotide polymorphisms (SNPs) belonging to 18 IIRGs were genotyped by the PCR-MassArray assay, and the obtained data was analyzed with ?2-test, Bonferroni correction, and unconditional logistic regression analysis. RESULTS:We observed significant differences in the allele frequency of LTA rs2229094*C (P?=?0.015), MBL2 rs2099902*C (P?=?0.001), MBL2 rs930507*G (P?=?0.004), MBL2 rs10824793*G (P?=?0.004), and IL12RB1 rs2305740*G (P?=?0.040) between the TB and healthy groups. Increased TB risk was identified in the rs930507 G/G genotype (Padjusted?=?0.027) under a codominant genetic model as well as in the rs2099902 (C/T?+?C/C) vs T/T genotype (Padjusted?=?0.020), rs930507 (C/G?+?G/G) vs C/C genotype (Padjusted?=?0.027), and rs10824793 (G/A?+?G/G) vs A/A genotype (Padjusted?=?0.017) under a dominant genetic model after Bonferroni correction in the analysis of the overall TB group rather than the TB subgroups. Furthermore, the rs10824793_rs7916582*GT and rs10824793_rs7916582*GC haplotypes were significantly associated with increased TB risk (P?=?0.001, odds ratio [OR]?=?1.421, 95% confidence interval [CI]: 1.152-1.753; and P?=?0.018, OR?=?1.364, 95% CI: 1.055-1.765, respectively). Moreover, the rs10824793_rs7916582*AT/AT or rs10824793_rs7916582*GT/GT diplotype showed a protective (P?=?0.003, OR?=?0.530, 95% CI: 0.349-0.805) or harmful (P?=?0.009, OR?=?1.396, 95% CI: 1.087-1.793) effect against the development of TB. CONCLUSIONS:This study indicated that MBL2 polymorphisms, haplotypes, and diplotypes were associated with TB susceptibility in the Han Chinese population. Additionally, larger sample size studies are needed to further confirm these findings in the future.

Dataset Information

Association between Mannose-binding lectin gene polymorphisms and hepatitis B virus infection: a meta-analysis.

Objective

Methods

Results

Conclusion

Publications

Association between Mannose-binding lectin gene polymorphisms and hepatitis B virus infection: a meta-analysis.

Similar Datasets

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