Ontology highlight
ABSTRACT:
SUBMITTER: Foster RW
PROVIDER: S-EPMC3793232 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Foster Robert W RW Tame Christopher J CJ Hailes Helen C HC Sheppard Tom D TD
Advanced synthesis & catalysis 20130801 11-12
(Cyclooctadiene)(pentamethylcyclopentadiene)ruthenium chloride [Cp*RuCl(cod)] has been used to catalyze the regioselective cyclization of amide-tethered diynes with monosubstituted alkynes to give polysubstituted isoindolinones. Notably, the presence of a trimethylsilyl group on the diyne generally led to complete control over the regioselectivity of the alkyne cyclotrimerization. The cyclization reaction worked well in a sustainable non-chlorinated solvent and was tolerant of moisture. The opti ...[more]