Ontology highlight
ABSTRACT:
SUBMITTER: Reece-Hoyes JS
PROVIDER: S-EPMC3794439 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Reece-Hoyes John S JS Pons Carles C Diallo Alos A Mori Akihiro A Shrestha Shaleen S Kadreppa Sreenath S Nelson Justin J Diprima Stephanie S Dricot Amelie A Lajoie Bryan R BR Ribeiro Philippe Souza Moraes PS Weirauch Matthew T MT Hill David E DE Hughes Timothy R TR Myers Chad L CL Walhout Albertha J M AJ
Molecular cell 20130620 1
Gene duplication results in two identical paralogs that diverge through mutation, leading to loss or gain of interactions with other biomolecules. Here, we comprehensively characterize such network rewiring for C. elegans transcription factors (TFs) within and across four newly delineated molecular networks. Remarkably, we find that even highly similar TFs often have different interaction degrees and partners. In addition, we find that most TF families have a member that is highly connected in m ...[more]