Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt D
PROVIDER: S-EPMC3008766 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Schmidt Dominic D Wilson Michael D MD Ballester Benoit B Schwalie Petra C PC Brown Gordon D GD Marshall Aileen A Kutter Claudia C Watt Stephen S Martinez-Jimenez Celia P CP Mackay Sarah S Talianidis Iannis I Flicek Paul P Odom Duncan T DT
Science (New York, N.Y.) 20100408 5981
Transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To explore the evolution of gene regulation, we used chromatin immunoprecipitation with high-throughput sequencing (ChIP-seq) to determine experimentally the genome-wide occupancy of two TFs, CCAAT/enhancer-binding protein alpha and hepatocyte nuclear factor 4 alpha, in the livers of five vertebrates. Although each TF displays highly conserved DNA binding preferences, most binding is species-specific, and al ...[more]