Ontology highlight
ABSTRACT:
SUBMITTER: Lee KM
PROVIDER: S-EPMC3794596 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Lee Ka-Ming KM Yusa Kazuyuki K Chu Lai-On LO Yu Conny Wing-Heng CW Oono Moe M Miyoshi Tomohiro T Ito Kosuke K Shaw Pang-Chui PC Wong Kam-Bo KB Uchiumi Toshio T
Nucleic acids research 20130726 18
Lateral ribosomal stalk is responsible for binding and recruiting translation factors during protein synthesis. The eukaryotic stalk consists of one P0 protein with two copies of P1•P2 heterodimers to form a P0(P1•P2)₂ pentameric P-complex. Here, we have solved the structure of full-length P1•P2 by nuclear magnetic resonance spectroscopy. P1 and P2 dimerize via their helical N-terminal domains, whereas the C-terminal tails of P1•P2 are unstructured and can extend up to ∼125 Å away from the dimer ...[more]