Potential targets for colorectal cancer prevention.
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ABSTRACT:
SUBMITTER: Temraz S
PROVIDER: S-EPMC3794728 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Publications
Potential targets for colorectal cancer prevention.
Temraz Sally S Mukherji Deborah D Shamseddine Ali A
International journal of molecular sciences 20130822 9
The step-wise development of colorectal neoplasia from adenoma to carcinoma suggests that specific interventions could delay or prevent the development of invasive cancer. Several key factors involved in colorectal cancer pathogenesis have already been identified including cyclooxygenase 2 (COX-2), nuclear factor kappa B (NF-κB), survivin and insulin-like growth factor-I (IGF-I). Clinical trials of COX-2 inhibitors have provided the "proof of principle" that inhibition of this enzyme can prevent ...[more]
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