Ontology highlight
ABSTRACT:
SUBMITTER: Voet A
PROVIDER: S-EPMC3794991 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Voet Arnout A Berenger Francois F Zhang Kam Y J KY
PloS one 20131010 10
One of the underlying principles in drug discovery is that a biologically active compound is complimentary in shape and molecular recognition features to its receptor. This principle infers that molecules binding to the same receptor may share some common features. Here, we have investigated whether the electrostatic similarity can be used for the discovery of small molecule protein-protein interaction inhibitors (SMPPIIs). We have developed a method that can be used to evaluate the similarity o ...[more]