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New world bats harbor diverse influenza A viruses.

ABSTRACT: Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit bats suggests that other New World species may similarly carry divergent influenza viruses. Using consensus degenerate RT-PCR, we identified a novel influenza A virus, designated as H18N11, in a flat-faced fruit bat (Artibeus planirostris) from Peru. Serologic studies with the recombinant H18 protein indicated that several Peruvian bat species were infected by this virus. Phylogenetic analyses demonstrate that, in some gene segments, New World bats harbor more influenza virus genetic diversity than all other mammalian and avian species combined, indicative of a long-standing host-virus association. Structural and functional analyses of the hemagglutinin and neuraminidase indicate that sialic acid is not a ligand for virus attachment nor a substrate for release, suggesting a unique mode of influenza A virus attachment and activation of membrane fusion for entry into host cells. Taken together, these findings indicate that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.

SUBMITTER: Tong S

PROVIDER: S-EPMC3794996 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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New world bats harbor diverse influenza A viruses.

Tong Suxiang S Zhu Xueyong X Li Yan Y Shi Mang M Zhang Jing J Bourgeois Melissa M Yang Hua H Chen Xianfeng X Recuenco Sergio S Gomez Jorge J Chen Li-Mei LM Johnson Adam A Tao Ying Y Dreyfus Cyrille C Yu Wenli W McBride Ryan R Carney Paul J PJ Gilbert Amy T AT Chang Jessie J Guo Zhu Z Davis Charles T CT Paulson James C JC Stevens James J Rupprecht Charles E CE Holmes Edward C EC Wilson Ian A IA Donis Ruben O RO

PLoS pathogens 20131010 10

Aquatic birds harbor diverse influenza A viruses and are a major viral reservoir in nature. The recent discovery of influenza viruses of a new H17N10 subtype in Central American fruit bats suggests that other New World species may similarly carry divergent influenza viruses. Using consensus degenerate RT-PCR, we identified a novel influenza A virus, designated as H18N11, in a flat-faced fruit bat (Artibeus planirostris) from Peru. Serologic studies with the recombinant H18 protein indicated that ...[more]

PMID: 24130481

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New world bats harbor diverse influenza A viruses.

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New world bats harbor diverse influenza A viruses.

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