Ontology highlight
ABSTRACT:
SUBMITTER: Le Bourhis L
PROVIDER: S-EPMC3795036 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Le Bourhis Lionel L Dusseaux Mathilde M Bohineust Armelle A Bessoles Stéphanie S Martin Emmanuel E Premel Virginie V Coré Maxime M Sleurs David D Serriari Nacer-Eddine NE Treiner Emmanuel E Hivroz Claire C Sansonetti Philippe P Gougeon Marie-Lise ML Soudais Claire C Lantz Olivier O
PLoS pathogens 20131010 10
Mucosal associated invariant T cells (MAIT) are innate T lymphocytes that detect a large variety of bacteria and yeasts. This recognition depends on the detection of microbial compounds presented by the evolutionarily conserved major-histocompatibility-complex (MHC) class I molecule, MR1. Here we show that MAIT cells display cytotoxic activity towards MR1 overexpressing non-hematopoietic cells cocultured with bacteria. The NK receptor, CD161, highly expressed by MAIT cells, modulated the cytokin ...[more]