Ontology highlight
ABSTRACT:
SUBMITTER: Arnold IC
PROVIDER: S-EPMC6590837 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
PLoS pathogens 20190612 6
The gastric lamina propria of mice that have been experimentally infected with the pathobiont Helicobacter pylori hosts a dense network of myeloid cells that includes BATF3-dependent CD103+ dendritic cells (DCs). We show here that CD103+ DCs are strictly required for gastric Th1 responses to H. pylori and for H. pylori infection control. A similar dependence of type 1 immunity on CD103+ DCs is observed in a Mycobacterium bovis BCG infection model, and in a syngeneic colon cancer model. Strikingl ...[more]