Ontology highlight
ABSTRACT:
SUBMITTER: Guiraldelli MF
PROVIDER: S-EPMC3797188 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Guiraldelli Michel F MF Eyster Craig C Pezza Roberto J RJ
DNA repair 20130727 10
RMI1 forms an evolutionarily conserved complex with BLM/TOP3α/RMI2 (BTR complex) to prevent and resolve aberrant recombination products, thereby promoting genome stability. Most of our knowledge about RMI1 function has been obtained from biochemical studies in vitro. In contrast, the role of RMI1 in vivo remains unclear. Previous attempts to generate an Rmi1 knockout mouse line resulted in pre-implantation embryonic lethality, precluding the use of mouse embryonic fibroblasts (MEFs) and embryoni ...[more]