Ontology highlight
ABSTRACT:
SUBMITTER: Chang M
PROVIDER: S-EPMC1142613 | biostudies-literature | 2005 Jun
REPOSITORIES: biostudies-literature
Chang Michael M Bellaoui Mohammed M Zhang Chaoying C Desai Ridhdhi R Morozov Pavel P Delgado-Cruzata Lissette L Rothstein Rodney R Freyer Greg A GA Boone Charles C Brown Grant W GW
The EMBO journal 20050512 11
SGS1 encodes a DNA helicase whose homologues in human cells include the BLM, WRN, and RECQ4 genes, mutations in which lead to cancer-predisposition syndromes. Clustering of synthetic genetic interactions identified by large-scale genetic network analysis revealed that the genetic interaction profile of the gene RMI1 (RecQ-mediated genome instability, also known as NCE4 and YPL024W) was highly similar to that of SGS1 and TOP3, suggesting a functional relationship between Rmi1 and the Sgs1/Top3 co ...[more]